Barcelona's fourth defeat of the season left them seventh in the standings on 14 points after 10 games, 12 points behind leaders Atletico.
Images from the Champions League matches played across Europe on Wednesday.
In what was a thrilling match of end to end action, Germany powered past Ukraine by a 1-0 margin in their Euro 2016 Group C campaign-opening match in Lille on Sunday.
Arsenal suffered a shock Europa League exit to Olympiakos Piraeus on away goals after a 2-1 extra-time home defeat, while Manchester United and Wolverhampton Wanderers cruised into the last 16 with emphatic aggregate wins on Thursday.
A round-up of Wednesday's league stage matches in the UEFA Champions League.
(Reuters) - Real Madrid, Manchester United and Paris St Germain reached the last 16 of the Champions League on Wednesday on a night when the goals flowed all over Europe with United the highest scorers in a 5-0 win at Bayer Leverkusen.
Chelsea enjoyed a somewhat fortuitous return to winning ways when they beat Aston Villa on Saturday but their fragile self-confidence will face a far more severe test at Dynamo Kiev in the Champions League on Tuesday.
News of all that transpired on and off the football field.
Manchester United's woes deepened as stunning goals by Moussa Sow and Jeremain Lens gave Fenerbahce a 2-1 Europa League win on Thursday that left Jose Mourinho's side facing a battle to reach the knockout stages.
Last season's runners-up Liverpool, big-spending French league champions Paris St Germain and Carlo Ancelotti's Napoli were thrown together in the pick of the groups while holders Real Madrid must face last season's semi-finalists AS Roma.
Images from Champions League matches played across Europe on Tuesday
Liverpool handed their fiercest rivals a painful lesson on Thursday with a dominant 2-0 win over Manchester United in the first leg of a Europa League last-16 clash.
Ruthless Bayern Munich scored five goals in the first 35 minutes on the way to a 7-1 demolition of AS Roma on Tuesday which bore an uncanny resemblance to Germany's win over Brazil by the same score in the World Cup semi-final.
Arsenal had scored 10 goals in two matches against BATE Borisov in the same competition in 2017 but never looked like being as prolific in the freezing temperatures of Belarus.
Aguero will not start against Man United: Guardiola.
England defender John Stones has been ruled out of their final two Euro 2016 qualifiers through injury, the FA said in a statement.
Manchester United ended their one-year Champions League hiatus in emphatic style when Wayne Rooney struck a hat-trick in a 4-0 destruction of Club Bruges that sent the three-times winners through 7-1 on aggregate on Wednesday.
Ten of the 16 sides also reached the same round two seasons ago and, as usual, the big five leagues dominate with 13 clubs hailing from either the English, Spanish, German, French and Italian leagues.
Images from the Champions League matches played on Wednesday
Paris St Germain will play Borussia Dortmund and Barcelona were pitted against an unpredictable Napoli, while Chelsea were drawn against Bayern Munich. City, who will be at home in the second leg, have yet to beat the Spanish side with two draws and two defeats in their previous four meetings.
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field
This and more from the happenings in the world of football.
With five titles, Barca are now level with AC Milan on all-time UEFA Super Cup winners list
Despite their first-leg advantage, Pochettino warned against complacency and said he wanted his team to play for another win, although they have had one day less to prepare than the Germans.
United's Ibrahimovic, Roma's Dzeko find the net thrice to give clubs first leg advantage
Atletico Madrid were handed a chance to avenge last season's Champions League final defeat by city rivals and record 10-times winners Real after the two sides were drawn together in the last eight on Friday. Paris St Germain and Barcelona were paired together having met in the group stage, with the French side winning in Paris and the Catalans coming out on top in Spain.
The unprecedented shutdown of world sport in response to the coronavirus spread that has infected more than 134,000 people and killed around 5,000 also prompted organisers to postpone the Formula One motor races in Vietnam and Bahrain. The start of the lucrative Indian Premier League has also been postponed until April 15 as a "precautionary measure", the Board of Control for Cricket in India said.
A round-up of Tuesday night's matches in the UEFA Champions League.
Images from the UEFA Champions League matches played on Wednesday night.
Earlier in the day, Russia was banned from defending its Davis Cup and Billie Jean King Cup titles but its players will still be allowed to compete at the Grand Slams and in regular tour events.
When Swedish champions Malmo take on mighty Real Madrid on Wednesday they do so knowing they would probably have to sell their entire squad just to be able to afford a single player from the bench of the Spanish giants.
Manchester United's hopes of salvaging their season in the Europa League suffered a stinging setback when they lost 2-1 at Danish side Midtjylland in the first leg of their last-32 clash on Thursday.
Images from the Champions League football matches played on Wednesday night.
Photos from the Champions League matches played across Europe on Tuesday.
Real Madrid got their Champions League title defence off to a strong start on Wednesday by convincingly beating AS Roma 3-0 at home with goals from Isco, Gareth Bale and a stoppage-time strike from returning striker Mariano Diaz.
News of all that transpired on and off the football field.
The three teams with 100 percent records in this season's Champions League can secure their places in the knockout stage this week with two games to spare.
Liverpool laboured to a 2-0 win over Denmark's Midtjylland on Tuesday as a goal from Diogo Jota and a Mohamed Salah penalty secured a hard-fought Champions League Group D victory at Anfield.
Everton have agreed to sign Barcelona's Colombia centre back Yerry Mina for an initial 30.25 million euros ($34.97 million) and have also taken the club's midfielder Andre Gomes on loan, the Spanish champions said on Thursday.
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